2. Neurological Disease

Neurological Disease

Neurological Disease

Related Products

PDF 88.0 MB

A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-28259
    2-Bromo-3',4'-(methylenedioxy)propiophenone 52190-28-0 98%
    2-Bromo-3',4'-(methylenedioxy)propiophenone is a precursor in the synthesis of drugs.
    2-Bromo-3',4'-(methylenedioxy)propiophenone
  • HY-34713
    N-Methylphenethylamine hydrochloride 4104-43-2 98%
    N-Methylphenethylamine (NMPEA) hydrochloride is a potent TAAR1 agonist. N-Methylphenethylamine hydrochloride also is a trace amine neuromodulator.
    N-Methylphenethylamine hydrochloride
  • HY-43421
    Solifenacin N-oxide 180272-28-0 98%
    Solifenacin N-oxide (Solifenacin N1-oxide) is an inactive metabolite of the muscarinic receptor antagonist Solifenacin (HY-A0034).
    Solifenacin N-oxide
  • HY-47412
    Cariprazine impurity 1 791778-53-5 ≥98.0%
    Cariprazine impurity 1 is a dopamine D2 receptor (D2R) agonist. Cariprazine impurity 1 modulates D2R-mediated Gi/o signaling pathway to inhibit cAMP production, and regulates D2R-mediated β-arrestin2 recruitment pathway.
    Cariprazine impurity 1
  • HY-47598
    Analgesic agent-3 796115-75-8 98%
    Analgesic agent-3 (compound 3d) is a potent analgesic agent.
    Analgesic agent-3
  • HY-59059
    5-(2-Aminopropyl)indole 3784-30-3 99.9%
    5-(2-Aminopropyl)indole is an orally active psychoactive substance, that shows inhibitory activity against monoamine oxidase (MAO) and long-lasting stimulatory properties.
    5-(2-Aminopropyl)indole
  • HY-60174
    2-BZP 84477-71-4 98%
    2-BZP is a piperazine.
    2-BZP
  • HY-70050
    Alosetron (Hydrochloride(1:X)) 132414-02-9 98%
    Alosetron (GR 68755) Hydrochloride(1:X) is a potent and highly selective serotonin 5-HT3 receptor antagonist. Alosetron Hydrochloride(1:X) is used for the research of irritable bowel syndrome (IBS). Alosetron Hydrochloride(1:X) blocks the fast 5HT3-mediated depolarisation of guinea-pig myenteric and submucosal neurons, with IC50 at ~55 nM. Alosetron Hydrochloride(1:X) attenuates the visceral nociceptive effect of rectal distension in conscious or anaesthetised dogs. Anti-inflammatory effects.
    Alosetron (Hydrochloride(1:X))
  • HY-70081
    Sumanirole 179386-43-7 98%
    Sumanirole (PNU-95666E) is a highly selective D2 receptor full agonist with an ED50 of about 46 nM. Sumanirole plays an important role in the research of Parkinson's disease and restless leg syndrome.
    Sumanirole
  • HY-A0164
    Cinolazepam 75696-02-5 98%
    Cinolazepam (Gerodorm) is a benzodiazepine.
    Cinolazepam
  • HY-A0232
    Heptabarbital 509-86-4 98%
    Heptabarbital (Medomin) is an oral activity Barbituric acid derivative. Heptabarbital has the potential for the research of insomnia.
    Heptabarbital
  • HY-B0163
    Detomidine 76631-46-4 98%
    Detomidine, an imidazole derivative, is a potent α2-adrenergic agonist. Detomidine produces dose-dependent analgesic effects.
    Detomidine
  • HY-B0528
    Octopamine 104-14-3 99.52%
    Octopamine is a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates. Octopamine can stimulate alpha2-adrenoceptors (ARs) in Chinese hamster ovary cells transfected with human alpha2-ARs. Octopamine increased glycogenolysis, glycolysis, oxygen uptake, gluconeogenesis and the portal perfusion pressure.
    Octopamine
  • HY-B0938
    Mephentermine hemisulfate 1212-72-2 98%
    Mephentermine is a sympathomimetic amine, frequently used as a vasopressor.
    Mephentermine hemisulfate
  • HY-B1375
    Pyrithyldione 77-04-3 98%
    Pyrithyldione is a sedative-hypnotic agent that induces agranulocytosis.
    Pyrithyldione
  • HY-B1542
    Benactyzine 302-40-9 98%
    Benactyzine is a competitive BChE inhibitor with a Ki of 0.01 mM. Benactyzine is an anticholinergic drug. Benactyzine has the potential for organophosphate poisoning research.
    Benactyzine
  • HY-B1606
    Chlorothymol 89-68-9
    Chlothymol is a potent positive modulator of the GABAA receptor subunit LGC-37, anticonvulsant, and antibacterial agent. Chlothymol inhibits Pentylenetetrazol-induced c-fos expression. Chlothymol inhibits the growth of Methicillin (HY-121544)-resistant Staphylococcus aureus (MRSA) strains, including LAC, with an MIC of 32 μg/mL. Chlorothymol has protective effects against epileptic seizures in various mouse models.
    Chlorothymol
  • HY-B1621
    Cyclopentolate 512-15-2 98%
    Cyclopentolate (DL-Cyclopentolate) is an Atropine-like muscarinic receptors antagonist with a pKB value of 7.8 (on the circular ciliary muscle). Cyclopentolate is an anti-muscarinic agent commonly used in the ophthalmologic practice.
    Cyclopentolate
  • HY-B1680
    Lithium citrate 919-16-4 98.0%
    Lithium citrate is a lithium supplement that reduces excess brain N-acetylaspartate (NAA) in Canavan disease. Canavan disease is an autosomal recessive leukodystrophy caused by mutations in the aspartate acylase (ASPA) gene, which catalyzes the hydrolysis of N-acetylaspartate (NAA) to acetate and aspartate.
    Lithium citrate
  • HY-D1684
    DCDAPH 125113-96-4 98%
    DCDAPH (Compound 2c) is a novel smart NIRF probe for detection of β-amyloid (Aβ) plaques (λex/λem=597/665 nm in PBS). DCDAPH shows high affinity for Aβ aggregates (Ki=37 nM, Kd=27 nM). DCDAPH shows good blood brain barrier permeation and can meet most of the requirements for the detection of Aβ plaques both in vitro and in vivo.
    DCDAPH
Cat. No. Product Name / Synonyms Application Reactivity